tmx1 thioredoxin-related transmembrane protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmx1provided by ZNC
Official Full Name: thioredoxin-related transmembrane protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2327
See related: Ensembl:ENSDARG00000019487 AllianceGenome:ZFIN:ZDB-GENE-030131-2327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: txndc; txndc1; wu:fc04g05
Summary: Predicted to enable disulfide oxidoreductase activity. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endomembrane system. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36923099..36933317)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36797267..36807485)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-related transmembrane protein 1

Names: thioredoxin domain containing 1

NP_001108605.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115133.1 → NP_001108605.1 thioredoxin-related transmembrane protein 1 precursor

Status: VALIDATED

Source sequence(s)

BC056715, DR722002

UniProtKB/TrEMBL

A0A8M1NI57, F1Q6B4, Q6PH50

Related

ENSDARP00000004160.5, ENSDART00000026313.8

Conserved Domains (1) summary

cd02994
Location:36 → 136

PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...