mecp2 methyl CpG binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mecp2provided by ZNC
Official Full Name: methyl CpG binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7190
See related: Ensembl:ENSDARG00000014218 AllianceGenome:ZFIN:ZDB-GENE-030131-7190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk96a04; zgc:111857
Summary: Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including axonogenesis involved in innervation; sensory perception of touch; and synapse organization. Predicted to be located in heterochromatin. Predicted to be active in nucleus. Is expressed in several structures, including heart; kidney; muscle; nervous system; and skeletal system. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (7616584..7637640, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (7597853..7618909, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mecp2 is required for tnfa expression during zebrafish development and inflammation.
Title: Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.
The results of this study imply that Mecp2 is an important functional regulator of bdnf gene expression during neural circuit formation in zebrafish embryo
Title: Zebrafish Mecp2 is required for proper axonal elongation of motor neurons and synapse formation.
a proteomic analysis to examine protein expression changes in mecp2-null vs. wild-type larvae and adult zebrafish
Title: Proteomic analysis of the Rett syndrome experimental model mecp2(Q63X) mutant zebrafish.
A mecp2-null allele mutation zebrafish model is developed and the animals are viable and fertile.
Title: The first mecp2-null zebrafish model shows altered motor behaviors.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded methylated DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded methylated DNA binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis involved in innervation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methyl-CpG-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.