ttyh2l tweety homolog 2, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttyh2lprovided by ZNC
Official Full Name: tweety homolog 2, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2394
See related: Ensembl:ENSDARG00000010727 AllianceGenome:ZFIN:ZDB-GENE-040426-2394
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ttyh2; zgc:85736; wu:fi03f07
Summary: Predicted to enable intracellularly calcium-gated chloride channel activity and volume-sensitive chloride channel activity. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Is expressed in adaxial cell; nervous system; neural tube; optic vesicle; and trigeminal placode. Orthologous to human TTYH2 (tweety family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (51563695..51657712)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (51308939..51403049)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables volume-sensitive chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tweety homolog 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213256.1 → NP_998421.1 protein tweety homolog 2-like

Status: PROVISIONAL

Source sequence(s)

BC068374

UniProtKB/Swiss-Prot

Q6NUZ2

UniProtKB/TrEMBL

A0A8M3B1A5

Related

ENSDARP00000018866.8, ENSDART00000008607.9

Conserved Domains (1) summary

pfam04906
Location:27 → 417

Tweety; Tweety