seh1l SEH1-like (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: seh1lprovided by ZNC
Official Full Name: SEH1-like (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6689
See related: Ensembl:ENSDARG00000004280 AllianceGenome:ZFIN:ZDB-GENE-030131-6689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa02g03; zgc:55977; wu:fa02g03
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; cellular response to amino acid starvation; and positive regulation of TORC1 signaling. Predicted to act upstream of or within several processes, including chromosome segregation; mRNA transport; and protein transport. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR2 complex and nuclear pore outer ring. Predicted to colocalize with kinetochore. Orthologous to human SEH1L (SEH1 like nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (12406583..12429254)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (12487055..12509726)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa02g05.r1 (e-PCR)
- UniSTS:189515

fa02g03.s1 (e-PCR)
- UniSTS:202151

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear pore organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Seh1-associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
colocalizes_with kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoporin SEH1

Names: GATOR complex protein SEH1; GATOR2 complex protein SEH1; nup107-160 subcomplex subunit seh1; sec13-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199923.2 → NP_956217.2 nucleoporin SEH1

See identical proteins and their annotated locations for NP_956217.2

Status: VALIDATED

Source sequence(s)

AA497203, BX294130, CT658356, CT667548, CT672475, CT711379

UniProtKB/Swiss-Prot

Q1LXR9, Q6TGU2

UniProtKB/TrEMBL

A0A8M9PRC2

Related

ENSDARP00000003173.8, ENSDART00000013865.10

Conserved Domains (3) summary

COG2319
Location:5 → 308

WD40; WD40 repeat [General function prediction only]

sd00039
Location:15 → 55

7WD40; WD40 repeat [structural motif]

cl02567
Location:11 → 306

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...