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    tssc4 tumor suppressing subtransferable candidate 4 [ Danio rerio (zebrafish) ]

    Gene ID: 559769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tssc4provided by ZNC
    Official Full Name
    tumor suppressing subtransferable candidate 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-263
    See related
    Ensembl:ENSDARG00000036144 AllianceGenome:ZFIN:ZDB-GENE-060825-263
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153225
    Summary
    Predicted to enable molecular sequestering activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be part of U5 snRNP. Predicted to be active in cytoplasm and nucleus. Orthologous to human TSSC4 (tumor suppressing subtransferable candidate 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tssc4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (32897732..32899840)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (32626562..32628690)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 member 6b Neighboring gene anoctamin 5b Neighboring gene anoctamin 9b Neighboring gene plakophilin 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells. Starr CJ, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983050, Free PMC Article
    2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153225

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U5 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U5 small nuclear ribonucleoprotein TSSC4
    Names
    protein TSSC4
    tumor-suppressing subchromosomal transferable fragment 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045848.1 → NP_001039313.1  U5 small nuclear ribonucleoprotein TSSC4

      See identical proteins and their annotated locations for NP_001039313.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122196
      UniProtKB/Swiss-Prot
      Q0P4A6
      UniProtKB/TrEMBL
      B2GNS7
      Related
      ENSDARP00000069747.4, ENSDART00000075263.5
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      32897732..32899840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168889.5 → XP_005168946.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168946.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Related
      ENSDARP00000113370.1, ENSDART00000133584.3
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    2. XM_005168886.5 → XP_005168943.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168943.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    3. XM_005168890.5 → XP_005168947.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168947.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Related
      ENSDARP00000154709.1, ENSDART00000188487.1
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    4. XM_005168885.5 → XP_005168942.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168942.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    5. XM_005168888.5 → XP_005168945.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168945.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    6. XM_005168884.5 → XP_005168941.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168941.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4

    7. XM_005168887.5 → XP_005168944.1  U5 small nuclear ribonucleoprotein TSSC4 isoform X1

      See identical proteins and their annotated locations for XP_005168944.1

      UniProtKB/TrEMBL
      A0A8M2BG61, F1Q8E9
      Conserved Domains (1) summary
      pfam15264
      Location:86 → 209
      TSSC4; Tumour suppressing sub-chromosomal transferable candidate 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P4A6.1 GenPept UniProtKB/Swiss-Prot:Q0P4A6

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