efna5b ephrin-A5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: efna5bprovided by ZNC
Official Full Name: ephrin-A5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-186
See related: Ensembl:ENSDARG00000098625 AllianceGenome:ZFIN:ZDB-GENE-980526-186
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: L4; al1; EPLG7; efna5; lerk7; tkral1; ZfEphL4
Summary: Predicted to enable ephrin receptor binding activity. Acts upstream of or within mesoderm migration involved in gastrulation and somitogenesis. Predicted to be located in side of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; hypochord; liver; midbrain neural keel; and retinal ganglion cell. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (1433654..1446207)
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003334680.2 (36644..36945, complement)
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003334681.2 (9757..10052)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (1377252..1398149)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003334680.2 (36644..36945, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors observed no interaction between efn-A5b and RET from zebrafish, this lack of association indicates how complex efn-A signaling is and suggests that there may be other molecules involved in efn-A5-induced RET signaling.
Title: Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.

Submit: New GeneRIF Correction

General gene information

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Markers

Y09669 (e-PCR)
- UniSTS:204665

tkral1 (e-PCR)
- UniSTS:205484

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin-A5b

Names: AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; tyrosine kinase ligand AL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.