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    csnk1g2b casein kinase 1, gamma 2b [ Danio rerio (zebrafish) ]

    Gene ID: 561724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csnk1g2bprovided by ZNC
    Official Full Name
    casein kinase 1, gamma 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-285
    See related
    Ensembl:ENSDARG00000034056 AllianceGenome:ZFIN:ZDB-GENE-060825-285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153415
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in endocytosis; positive regulation of canonical Wnt signaling pathway; and signal transduction. Predicted to act upstream of or within Wnt signaling pathway and protein phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See csnk1g2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (20495936..20559956)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (20463804..20527871)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene REX1, RNA exonuclease 1 homolog Neighboring gene diencephalon/mesencephalon homeobox 2 Neighboring gene major facilitator superfamily domain containing 12b Neighboring gene nuclear factor I/C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CK1 gene family: expression patterning in zebrafish development. Albornoz A, et al. Biol Res, 2007. PMID 18064361
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153415

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I; casein kinase I isoform gamma-3
    NP_001039315.1
    NP_001277265.1
    XP_005166916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045850.2 → NP_001039315.1  casein kinase I isoform gamma-3 isoform 1

      See identical proteins and their annotated locations for NP_001039315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      BX323082
      UniProtKB/TrEMBL
      B2GPY9, Q0P446
      Related
      ENSDARP00000091101.3, ENSDART00000100328.4
      Conserved Domains (3) summary
      COG0515
      Location:42 → 411
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 403
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_001290336.1 → NP_001277265.1  casein kinase I isoform gamma-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX323082
      UniProtKB/TrEMBL
      A0A8M1P0J7, B0S603
      Related
      ENSDARP00000012086.8, ENSDART00000021683.10
      Conserved Domains (3) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam00069
      Location:43 → 300
      Pkinase; Protein kinase domain
      pfam12605
      Location:329 → 369
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      20495936..20559956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166859.5 → XP_005166916.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_005166916.1

      UniProtKB/TrEMBL
      B2GPY9, Q0P446
      Conserved Domains (3) summary
      COG0515
      Location:42 → 411
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 403
      CK1gamma_C; Casein kinase 1 gamma C terminal

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394719.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      6677..72982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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