elf3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elf3provided by ZNC
Official Full Name: E74-like factor 3 (ets domain transcription factor, epithelial-specific )provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8760
See related: Ensembl:ENSDARG00000077982 AllianceGenome:ZFIN:ZDB-GENE-030131-8760
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb06f04
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within cartilage morphogenesis; fin morphogenesis; and neuron projection development. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; liver primordium; nervous system; and trunk. Orthologous to human ELF3 (E74 like ETS transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (661516..664774)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (623663..627416)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis.
Title: Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

AI397189 (e-PCR)
- UniSTS:206670

fb06f04.x1 (e-PCR)
- UniSTS:202716

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ETS-related transcription factor Elf-3

Names: E74-like ETS transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

661516..664774

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002666100.4 → XP_002666146.1 ETS-related transcription factor Elf-3

UniProtKB/TrEMBL

A0A8M1REB6, E7FB26

Related

ENSDARP00000101728.2, ENSDART00000113795.4

Conserved Domains (2) summary

cd08537
Location:42 → 122

SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators

smart00413
Location:279 → 365

ETS; erythroblast transformation specific domain