hcst hematopoietic cell signal transducer [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hcstprovided by ZNC
Official Full Name: hematopoietic cell signal transducerprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061130-1
See related: Ensembl:ENSDARG00000092074 AllianceGenome:ZFIN:ZDB-GENE-061130-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dap10
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity and signaling receptor binding activity. Predicted to act upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and regulation of immune response. Predicted to be located in membrane. Is expressed in liver; lymphocyte; and pleuroperitoneal region. Orthologous to human HCST (hematopoietic cell signal transducer). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (25184209..25188121)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (25269177..25273089)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of the adaptor protein dap10 has been identified in the zebrafish genome.
Title: Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hematopoietic cell signal transducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100102.2 → NP_001093572.2 hematopoietic cell signal transducer precursor

Status: VALIDATED

Source sequence(s)

BX571853, EH454362

UniProtKB/TrEMBL

A0A8M1NE56, F1QIP7

Related

ENSDARP00000114360.1, ENSDART00000147584.2

Conserved Domains (1) summary

pfam07213
Location:1 → 73

DAP10; DAP10 membrane protein