U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ptgs1 prostaglandin-endoperoxide synthase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 246226, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ptgs1provided by ZNC
    Official Full Name
    prostaglandin-endoperoxide synthase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020530-1
    See related
    Ensembl:ENSDARG00000052148 AllianceGenome:ZFIN:ZDB-GENE-020530-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cox1; zCOX-1
    Summary
    Enables peroxidase activity and prostaglandin-endoperoxide synthase activity. Acts upstream of or within several processes, including embryonic liver development; exocrine pancreas development; and vasculogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including cardiovascular system; digestive system; eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ptgs1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (64907368..64946436)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (64226204..64265272)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene keratin, type 1, gene c5 Neighboring gene LIM homeobox 6b Neighboring gene uncharacterized LOC101882342 Neighboring gene annexin A1d

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cyclooxygenase-1 as a Potential Therapeutic Target for Seizure Suppression: Evidences from Zebrafish Pentylenetetrazole-Seizure Model. Barbalho PG, et al. Front Neurol, 2016. PMID 27895618, Free PMC Article
    2. The COXes of Danio: from mechanistic model to experimental therapeutics. Prescott SM, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12093922, Free PMC Article
    3. LH signaling induced ptgs2a expression is required for ovulation in zebrafish. Tang H, et al. Mol Cell Endocrinol, 2017 May 15. PMID 28254490
    4. Prostaglandins prevent acetaminophen induced embryo toxicity in zebrafish (Danio rerio). Galus M, et al. Environ Toxicol Pharmacol, 2020 Nov. PMID 32822849
    5. The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes. Ishikawa TO, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17112475, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin-endoperoxide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin-endoperoxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin-endoperoxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cyclooxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prostaglandin G/H synthase 1
    Names
    Cox-1
    Cox-1b
    NP_705942.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153656.2 → NP_705942.1  prostaglandin G/H synthase 1 precursor

      See identical proteins and their annotated locations for NP_705942.1

      Status: PROVISIONAL

      Source sequence(s)
      AY028584
      UniProtKB/TrEMBL
      Q8JH44
      Related
      ENSDARP00000104772.2, ENSDART00000122863.3
      Conserved Domains (2) summary
      cd09816
      Location:90 → 576
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      pfam00008
      Location:36 → 68
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      64907368..64946436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.