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    cables2a Cdk5 and Abl enzyme substrate 2a [ Danio rerio (zebrafish) ]

    Gene ID: 100148748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cables2aprovided by ZNC
    Official Full Name
    Cdk5 and Abl enzyme substrate 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091118-58
    See related
    Ensembl:ENSDARG00000076964 AllianceGenome:ZFIN:ZDB-GENE-091118-58
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-202m22.8
    Summary
    Predicted to act upstream of or within regulation of cell cycle. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cables2a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (30898005..30920943)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (30971465..30994690)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene delta-type opioid receptor Neighboring gene XK related 7a Neighboring gene oxysterol binding protein-like 2a Neighboring gene si:ch211-197l9.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDK5 and ABL1 enzyme substrate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      30898005..30920943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001919790.8 → XP_001919825.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q830, E9QCE8
      Related
      ENSDARP00000116145.1, ENSDART00000146859.2
      Conserved Domains (2) summary
      cd00043
      Location:389 → 480
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl28033
      Location:2 → 191
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. XM_005162339.5 → XP_005162396.1  CDK5 and ABL1 enzyme substrate 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B986
      Conserved Domains (2) summary
      cd00043
      Location:363 → 454
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl28033
      Location:2 → 191
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395158.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      629394..652332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473725.2 → XP_021329400.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q830, E9QCE8
      Conserved Domains (2) summary
      cd00043
      Location:389 → 480
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl28033
      Location:2 → 191
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. XM_021473726.2 → XP_021329401.1  CDK5 and ABL1 enzyme substrate 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B986
      Conserved Domains (2) summary
      cd00043
      Location:363 → 454
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl28033
      Location:2 → 191
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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