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    scel sciellin [ Danio rerio (zebrafish) ]

    Gene ID: 368684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scelprovided by ZNC
    Official Full Name
    sciellinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-15
    See related
    Ensembl:ENSDARG00000034677 AllianceGenome:ZFIN:ZDB-GENE-030616-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc20b10; si:by173d22.2
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in epidermis development. Predicted to be active in cytoplasm. Is expressed in corneal epithelium. Orthologous to human SCEL (sciellin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scel in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (17306160..17334589)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (17298420..17326937)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490345 Neighboring gene MYC binding protein 2 Neighboring gene uncharacterized LOC137496462 Neighboring gene uncharacterized LOC137490765 Neighboring gene SLAIN motif family, member 1a Neighboring gene wu:fc50b12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. Mohseny AB, et al. J Pathol, 2012 Jun. PMID 22297719
    2. Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. Takamiya M, et al. PLoS One, 2015. PMID 25692557, Free PMC Article
    3. A temporal single cell transcriptome atlas of zebrafish anterior segment development. Vöcking O, et al. Sci Rep, 2023 Apr 6. PMID 37024546, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sciellin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005304.1 → NP_001005304.1  sciellin

      See identical proteins and their annotated locations for NP_001005304.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645826
      UniProtKB/TrEMBL
      Q8AW38
      Conserved Domains (1) summary
      smart00132
      Location:504 → 543
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      17306160..17334589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167970.5 → XP_005168027.1  sciellin isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFF4, A8WHU6, F1QC88
      Related
      ENSDARP00000070406.4, ENSDART00000075926.6
      Conserved Domains (1) summary
      smart00132
      Location:544 → 583
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. XM_021478625.2 → XP_021334300.1  sciellin isoform X2

      UniProtKB/TrEMBL
      A0A8M9QJJ6
      Conserved Domains (1) summary
      smart00132
      Location:477 → 516
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394745.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      500538..528912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395276.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      162640..197748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395383.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      39475..67851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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