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    garem GRB2 associated, regulator of MAPK1 [ Danio rerio (zebrafish) ]

    Gene ID: 393138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    garemprovided by ZNC
    Official Full Name
    GRB2 associated, regulator of MAPK1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-767
    See related
    Ensembl:ENSDARG00000017242 AllianceGenome:ZFIN:ZDB-GENE-040426-767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam59a; garem1; zgc:55634
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within positive regulation of cell division. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See garem in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41340696..41348574)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41060623..41068501)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 2 Neighboring gene neutrophil cytosolic factor 2 Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene uncharacterized LOC137496192

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55634

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables proline-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-associated and regulator of MAPK protein 1
    Names
    GRB2-associated and regulator of MAPK1
    family with sequence similarity 59, member A
    protein FAM59A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200169.2 → NP_956463.1  GRB2-associated and regulator of MAPK protein 1

      See identical proteins and their annotated locations for NP_956463.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045411
      UniProtKB/Swiss-Prot
      Q7ZVU1
      Related
      ENSDARP00000024393.7, ENSDART00000005127.10
      Conserved Domains (2) summary
      cd09525
      Location:799 → 865
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:32 → 325
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      41340696..41348574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVU1.1 GenPept UniProtKB/Swiss-Prot:Q7ZVU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.