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    tnikb TRAF2 and NCK interacting kinase b [ Danio rerio (zebrafish) ]

    Gene ID: 556959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tnikbprovided by ZNC
    Official Full Name
    TRAF2 and NCK interacting kinase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051113-320
    See related
    AllianceGenome:ZFIN:ZDB-GENE-051113-320
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6898857; zgc:123033; zgc:152783
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in central nervous system; neural plate; retina; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tnikb in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26492667..26632201, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26344025..26487177, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22-like 1 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene rho-associated protein kinase 1-like Neighboring gene rho-associated protein kinase 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Lariat intronic RNAs in the cytoplasm of vertebrate cells. Talhouarne GJS, et al. Proc Natl Acad Sci U S A, 2018 Aug 21. PMID 30082412, Free PMC Article
    2. Heritable gene targeting in zebrafish using customized TALENs. Huang P, et al. Nat Biotechnol, 2011 Aug 5. PMID 21822242
    3. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123033, MGC152783, MGC192776

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAF2 and NCK interacting kinase b
    NP_001032765.2
    XP_005162835.1
    XP_005162836.1
    XP_005162837.1
    XP_068073178.1
    XP_068073179.1
    XP_068073181.1
    XP_068073182.1
    XP_068073183.1
    XP_068073184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037676.2 → NP_001032765.2  TRAF2 and NCK interacting kinase b

      Status: INFERRED

      Source sequence(s)
      CR354583, CR354593
      UniProtKB/TrEMBL
      A0A8M1N866, A0A8M9P5X5
      Conserved Domains (3) summary
      smart00036
      Location:1011 → 1309
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      26492667..26632201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217083.1 → XP_068073184.1  TRAF2 and NCK interacting kinase b isoform X9

      UniProtKB/TrEMBL
      A0A8M9PG24

    2. XM_005162780.5 → XP_005162837.1  TRAF2 and NCK interacting kinase b isoform X7

      UniProtKB/TrEMBL
      A0A8M2B9T3, A0A8M9PG24
      Conserved Domains (3) summary
      smart00036
      Location:974 → 1272
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    3. XM_068217080.1 → XP_068073181.1  TRAF2 and NCK interacting kinase b isoform X4

      UniProtKB/TrEMBL
      A0A8M9PLU4

    4. XM_068217077.1 → XP_068073178.1  TRAF2 and NCK interacting kinase b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PLU4

    5. XM_068217082.1 → XP_068073183.1  TRAF2 and NCK interacting kinase b isoform X8

      UniProtKB/TrEMBL
      A0A8M9P5X5

    6. XM_005162779.5 → XP_005162836.1  TRAF2 and NCK interacting kinase b isoform X6

      UniProtKB/TrEMBL
      A0A8M2B9R1, A0A8M9P5X5
      Conserved Domains (3) summary
      smart00036
      Location:1003 → 1301
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    7. XM_068217078.1 → XP_068073179.1  TRAF2 and NCK interacting kinase b isoform X3

      UniProtKB/TrEMBL
      A0A8M9PXJ4

    8. XM_068217081.1 → XP_068073182.1  TRAF2 and NCK interacting kinase b isoform X5

      UniProtKB/TrEMBL
      A0A8M9PU45

    9. XM_005162778.5 → XP_005162835.1  TRAF2 and NCK interacting kinase b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA19, A0A8M9PG19
      Conserved Domains (3) summary
      smart00036
      Location:1121 → 1419
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001075107.1: Suppressed sequence

      Description
      NM_001075107.1: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein
    Heading Accession and Version

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