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    c6.2 complement component 6, duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 393611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    c6.2provided by ZNC
    Official Full Name
    complement component 6, duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100513-4
    See related
    Ensembl:ENSDARG00000057113 AllianceGenome:ZFIN:ZDB-GENE-100513-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    c6; zgc:64073; si:ch211-22d5.4
    Summary
    Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See c6.2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20915459..20932662, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20878823..20896084, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial-like Neighboring gene complement component 7b Neighboring gene regulator of G protein signaling 7 binding protein b Neighboring gene ring finger protein 180b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Reuter H, et al. Cells, 2022 Jan 20. PMID 35159152, Free PMC Article
    2. Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Fu X, et al. Dev Comp Immunol, 2021 Sep. PMID 34004267
    3. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Wang Z, et al. Fish Shellfish Immunol, 2008 Sep. PMID 18657447
    4. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Li L, et al. Mol Immunol, 2020 Dec. PMID 33160183
    5. Xirp proteins mark injured skeletal muscle in zebrafish. Otten C, et al. PLoS One, 2012. PMID 22355335, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64073

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement component C6
    Names
    complement component 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200638.2 → NP_956932.2  complement component C6 precursor

      Status: VALIDATED

      Source sequence(s)
      BX511186
      UniProtKB/TrEMBL
      A0A0R4IXC5, A0A8M2B846, A0A8N7XIZ7, F6NHD3, Q6PFT2
      Related
      ENSDARP00000074161.3, ENSDART00000079709.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      20915459..20932662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161158.5 → XP_005161215.1  complement component C6 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IXC5, A0A8M2B846, A0A8N7XIZ7, F6NHD3, Q6PFT2
      Conserved Domains (5) summary
      cd00033
      Location:614 → 670
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00057
      Location:833 → 903
      FIMAC; factor I membrane attack complex
      smart00209
      Location:537 → 581
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:143 → 174
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:268 → 483
      MACPF; MAC/Perforin domain

    2. XM_005161159.5 → XP_005161216.1  complement component C6 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IXC5, A0A8M2B830, A0A8N7XIZ7, F6NHD3, Q6PFT2
      Conserved Domains (5) summary
      cd00033
      Location:614 → 670
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00057
      Location:768 → 838
      FIMAC; factor I membrane attack complex
      smart00209
      Location:537 → 581
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:143 → 174
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:268 → 483
      MACPF; MAC/Perforin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395089.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      90744..107888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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