adh8b alcohol dehydrogenase 8b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adh8bprovided by ZNC
Official Full Name: alcohol dehydrogenase 8bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030529-2
See related: Ensembl:ENSDARG00000024278 AllianceGenome:ZFIN:ZDB-GENE-030529-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables alcohol dehydrogenase (NAD+) activity and formaldehyde dehydrogenase (NAD+) activity. Acts upstream of or within formaldehyde metabolic process and octanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (12633218..12646753, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (12500751..12514277, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADH8a and ADH8b from zebrafish are conserved among species and expressed in developmental and adult tissue
Title: Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics.

Submit: New GeneRIF Correction

General gene information

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Markers

fj11b01.y1 (e-PCR)
- UniSTS:198516

fb23g01.y1 (e-PCR)
- UniSTS:190326

fc84e12.x1 (e-PCR)
- UniSTS:188336

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables formaldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alcohol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within formaldehyde metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within octanol metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alcohol dehydrogenase 8b

Names: mixed alcohol dehydrogenase Adh8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203460.1 → NP_982285.1 alcohol dehydrogenase 8b

See identical proteins and their annotated locations for NP_982285.1

Status: PROVISIONAL

Source sequence(s)

AY309075

UniProtKB/TrEMBL

A8KBZ0, Q7T2J4

Related

ENSDARP00000042765.5, ENSDART00000042766.6

Conserved Domains (1) summary

cl16912
Location:8 → 373

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

12633218..12646753 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480549.2 → XP_021336224.1 alcohol dehydrogenase 8b isoform X1

UniProtKB/TrEMBL

A8KBZ0, Q7T2J4

Conserved Domains (1) summary

cl16912
Location:8 → 373

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family