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    maptb microtubule-associated protein tau b [ Danio rerio (zebrafish) ]

    Gene ID: 567833, updated on 4-Jan-2025

    Summary

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    Official Symbol
    maptbprovided by ZNC
    Official Full Name
    microtubule-associated protein tau bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081027-2
    See related
    Ensembl:ENSDARG00000087616 AllianceGenome:ZFIN:ZDB-GENE-081027-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See maptb in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (22158021..22216455, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (22027473..22085882, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 27 Neighboring gene KAT8 regulatory NSL complex subunit 1b Neighboring gene myosin, light chain 4, alkali; atrial, embryonic Neighboring gene sodium channel, voltage-gated, type IV, alpha, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. Chen M, et al. J Alzheimers Dis, 2009. PMID 19584432
    2. Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies. Köglsberger S, et al. Mol Neurobiol, 2017 Dec. PMID 27878758, Free PMC Article
    3. Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. Moussavi Nik SH, et al. BMC Res Notes, 2014 Oct 31. PMID 25359609, Free PMC Article
    4. Garcinol pacifies acrylamide induced cognitive impairments, neuroinflammation and neuronal apoptosis by modulating GSK signaling and activation of pCREB by regulating cathepsin B in the brain of zebrafish larvae. Sharma C, et al. Food Chem Toxicol, 2020 Apr. PMID 32156567
    5. Folate deprivation induced neuroinflammation impairs cognition. Shaikh A, et al. Neurosci Lett, 2023 Jun 11. PMID 37086862

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo.
      Title: Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo.
    2. Hypoxia can alter splicing of zebrafish MAPT co-orthologues promoting formation of longer transcripts and possibly generating Mapt proteins more prone to hyperphosphorylation.
      Title: Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein tau

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      22158021..22216455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218902.1 → XP_068075003.1  microtubule-associated protein tau isoform X5

      UniProtKB/TrEMBL
      A0A8M2BIX4

    2. XM_068218901.1 → XP_068075002.1  microtubule-associated protein tau isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q3A3

    3. XM_068218898.1 → XP_068074999.1  microtubule-associated protein tau isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q3A3

    4. XM_021473452.2 → XP_021329127.1  microtubule-associated protein tau isoform X6

      UniProtKB/TrEMBL
      A0A8M9PDF7, A0A8M9Q3A3
      Conserved Domains (2) summary
      pfam00418
      Location:619 → 648
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:266 → 581
      Atrophin-1; Atrophin-1 family

    5. XM_068218896.1 → XP_068074997.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q3A3

    6. XM_068218899.1 → XP_068075000.1  microtubule-associated protein tau isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q7D2
      Related
      ENSDARP00000106770.2, ENSDART00000130546.3

    7. XM_068218897.1 → XP_068074998.1  microtubule-associated protein tau isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q3A3
    Nucleotide Protein Strain
    Heading Accession and Version

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