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    odad2 outer dynein arm docking complex subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 799229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    odad2provided by ZNC
    Official Full Name
    outer dynein arm docking complex subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100316-7
    See related
    Ensembl:ENSDARG00000055128 AllianceGenome:ZFIN:ZDB-GENE-100316-7
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    armc4; sb:eu579; sb:eu854; sb:eu947
    Summary
    Acts upstream of or within determination of heart left/right asymmetry. Is expressed in several structures, including Kupffer's vesicle; central nervous system; intestinal bulb primordium; neural rod; and pronephric duct. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See odad2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23026723..23153133, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (22905320..23031896, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene RAB18A, member RAS oncogene family Neighboring gene mohawk homeobox a Neighboring gene MAGUK p55 scaffold protein 7a Neighboring gene WW domain containing adaptor with coiled-coil a Neighboring gene BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates. Yamaguchi H, et al. Elife, 2023 Apr 14. PMID 37057896, Free PMC Article
    2. ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Hjeij R, et al. Am J Hum Genet, 2013 Aug 8. PMID 23849778, Free PMC Article
    3. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
    4. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
    5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer dynein arm docking complex subunit 2; outer dynein arm-docking complex subunit 2
    Names
    armadillo repeat containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      23026723..23153133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306737.4 → XP_009305012.1  outer dynein arm-docking complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_009305012.1

      UniProtKB/TrEMBL
      A0A8M3BE90, A0A8M9PTI1, E7FB07
      Conserved Domains (4) summary
      sd00044
      Location:923 → 961
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:543 → 568
      ARM; armadillo repeat [structural motif]
      pfam13646
      Location:845 → 950
      HEAT_2; HEAT repeats
      cl25709
      Location:634 → 865
      Arm_3; Atypical Arm repeat

    2. XM_021480320.2 → XP_021335995.1  outer dynein arm-docking complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PTI1, A0A8M9QMY0
      Conserved Domains (2) summary
      sd00043
      Location:543 → 568
      ARM; armadillo repeat [structural motif]
      cl25709
      Location:634 → 865
      Arm_3; Atypical Arm repeat

    3. XM_005156229.5 → XP_005156286.1  outer dynein arm-docking complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_005156286.1

      UniProtKB/TrEMBL
      A0A8M3BE90, A0A8M9PTI1, E7FB07
      Related
      ENSDARP00000071920.3, ENSDART00000077453.5
      Conserved Domains (4) summary
      sd00044
      Location:923 → 961
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:543 → 568
      ARM; armadillo repeat [structural motif]
      pfam13646
      Location:845 → 950
      HEAT_2; HEAT repeats
      cl25709
      Location:634 → 865
      Arm_3; Atypical Arm repeat

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394841.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      77156..152552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218679.1 → XP_068074780.1  outer dynein arm-docking complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PTI1
    Nucleotide Protein Strain
    Heading Accession and Version

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