csrp1a cysteine and glycine-rich protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: csrp1aprovided by ZNC
Official Full Name: cysteine and glycine-rich protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-4
See related: Ensembl:ENSDARG00000006603 AllianceGenome:ZFIN:ZDB-GENE-030909-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb796; csrp1; zgc:77332
Summary: Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Acts upstream of or within several processes, including JNK cascade; gastrulation; and neuron projection regeneration. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including axial hypoblast; axis; brainstem; cardiovascular system; and mesoderm. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (5765514..5783404, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (5831542..5849432, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study is the first to demonstrate the requirement of CRP1a for zebrafish spinal cord regeneration.
Title: Cysteine- and glycine-rich protein 1a is involved in spinal cord regeneration in adult zebrafish.
An essential factor that connects noncanonical Wnt And JNK signals to cell behaviors and migration through interactions with Dishevelled 2 (Dvl2) and Diversin (Div).
Title: Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine and glycine-rich protein 1a

Names: cysteine and glycine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205567.1 → NP_991130.1 cysteine and glycine-rich protein 1a

See identical proteins and their annotated locations for NP_991130.1

Status: PROVISIONAL

Source sequence(s)

BC065956

UniProtKB/TrEMBL

A0A8M1PCV2, Q6NZV4

Related

ENSDARP00000002532.6, ENSDART00000019455.8

Conserved Domains (2) summary

cd09403
Location:118 → 171

LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)

cd09479
Location:7 → 62

LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)