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    recql RecQ helicase-like [ Danio rerio (zebrafish) ]

    Gene ID: 566018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    recqlprovided by ZNC
    Official Full Name
    RecQ helicase-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-134
    See related
    Ensembl:ENSDARG00000007175 AllianceGenome:ZFIN:ZDB-GENE-050809-134
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110631
    Summary
    Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA recombination; DNA repair; and DNA replication. Predicted to be located in nucleus. Predicted to be active in chromosome and cytoplasm. Is expressed in basal plate midbrain region; central nervous system; and presumptive diencephalon. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See recql in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17524284..17538270)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17535304..17549294)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884203 Neighboring gene achaete-scute family bHLH transcription factor 1a Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Annus T, et al. Cell Death Dis, 2022 Apr 18. PMID 35436990, Free PMC Article
    2. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. van der Vaart M, et al. Cell Host Microbe, 2014 Jun 11. PMID 24922577
    3. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
    4. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110631

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase Q1
    Names
    RecQ protein-like (DNA helicase Q1-like)
    NP_001038561.2
    XP_005164818.1
    XP_068075795.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045096.2 → NP_001038561.2  ATP-dependent DNA helicase Q1

      See identical proteins and their annotated locations for NP_001038561.2

      Status: PROVISIONAL

      Source sequence(s)
      BC100012
      UniProtKB/TrEMBL
      A0A0R4ICY7, A0A8M1N9Y1, F1Q4T3, Q498Z7
      Related
      ENSDARP00000130578.2, ENSDART00000172169.2
      Conserved Domains (5) summary
      TIGR00614
      Location:89 → 542
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd00079
      Location:291 → 421
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:99 → 267
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:426 → 482
      RecQ_Zn_bind; RecQ zinc-binding
      cl09632
      Location:488 → 594
      RQC; RQC domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17524284..17538270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219694.1 → XP_068075795.1  ATP-dependent DNA helicase Q1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4ICY7, A0A8M1N9Y1, F1Q4T3, Q498Z7
      Related
      ENSDARP00000013573.8, ENSDART00000021610.10

    2. XM_005164761.5 → XP_005164818.1  ATP-dependent DNA helicase Q1 isoform X1

      See identical proteins and their annotated locations for XP_005164818.1

      UniProtKB/TrEMBL
      A0A8M9PHB7
      Conserved Domains (2) summary
      cl26939
      Location:89 → 542
      DEXDc; DEAD-like helicases superfamily
      cl27769
      Location:599 → 734
      GTP_EFTU; Elongation factor Tu GTP binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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