cryaa crystallin, alpha A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cryaaprovided by ZNC
Official Full Name: crystallin, alpha Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020508-1
See related: Ensembl:ENSDARG00000053502 AllianceGenome:ZFIN:ZDB-GENE-020508-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92036; wu:fc06h04
Summary: Enables unfolded protein binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in cytoplasm and nucleus. Is expressed in eye; lens; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (29096907..29100918)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (28293075..28297086)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of alpha-crystallin protein loss on zebrafish lens development.
Title: Impact of α-crystallin protein loss on zebrafish lens development.
that crystallin sequence evolution and expression defects may contribute to the loss of eyes in cavefish
Title: Lens defects in Astyanax mexicanus Cavefish: evolution of crystallins and a role for alphaA-crystallin.
The normal development observed in alphaA-crystallin deficient zebrafish embryos may reflect similarly non-essential roles for this protein in the early stages of both zebrafish and mammalian lens development.
Title: Loss of the small heat shock protein αA-crystallin does not lead to detectable defects in early zebrafish lens development.
Fndings establish that the C-terminal extension of alphaA crystallin can be either 3D domain swapped or non-3D domain swapped.
Title: Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin.
alphaA-crystallin (HSPB4) is expressed during development.
Title: Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables structural constituent of eye lens	NAS Non-traceable Author Statement more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within eye development	IDA Inferred from Direct Assay more info	PubMed
involved_in lens development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-crystallin A chain

Names: [a]A-crystallin; hspb4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152950.2 → NP_694482.1 alpha-crystallin A chain

See identical proteins and their annotated locations for NP_694482.1

Status: PROVISIONAL

Source sequence(s)

BC083177

UniProtKB/TrEMBL

B2GQV6, Q8UUZ6

Related

ENSDARP00000070021.5, ENSDART00000075539.6

Conserved Domains (3) summary

COG0071
Location:64 → 146

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]

pfam00525
Location:1 → 48

Crystallin; Alpha crystallin A chain, N terminal

cl00175
Location:61 → 146

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.