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    cpeb4a cytoplasmic polyadenylation element binding protein 4a [ Danio rerio (zebrafish) ]

    Gene ID: 393956, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cpeb4aprovided by ZNC
    Official Full Name
    cytoplasmic polyadenylation element binding protein 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1557
    See related
    Ensembl:ENSDARG00000056691 AllianceGenome:ZFIN:ZDB-GENE-040426-1557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Cpeb3; cpeb4; zgc:66166
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Predicted to act upstream of or within regulation of translation. Predicted to be located in dendrite; endoplasmic reticulum; and postsynaptic density. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Is expressed in cranial ganglion; neurons; olfactory placode; peripheral olfactory organ; and yolk syncytial layer. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See cpeb4a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24096588..24110736, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23794373..23813519, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-277c7.7 Neighboring gene muscle segment homeobox 2a Neighboring gene stanniocalcin 2a Neighboring gene NK2 homeobox 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66166

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to decreased oxygen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic polyadenylation element-binding protein 4
    Names
    CPE-binding protein 4
    cytoplasmatic polyadenylation element binding protein 4
    cytoplasmic polyadenylation element binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351720.1 → NP_001338649.1  cytoplasmic polyadenylation element-binding protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL935195, EH486763, EH535381
      UniProtKB/Swiss-Prot
      Q7SXN4
      UniProtKB/TrEMBL
      A0A286YBB6, A0A8M1P9S4, B2GRL1, F1QCY1
      Related
      ENSDARP00000109818.1, ENSDART00000123152.3
      Conserved Domains (3) summary
      cd12724
      Location:446 → 537
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:554 → 634
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:629 → 690
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    2. NM_200981.2 → NP_957275.2  cytoplasmic polyadenylation element-binding protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL935195, EH535381
      UniProtKB/Swiss-Prot
      Q7SXN4
      UniProtKB/TrEMBL
      A0A286YBB6, A0A8M1P9S4, B2GRL1, F1QCY1
      Related
      ENSDARP00000073682.4, ENSDART00000079226.6
      Conserved Domains (3) summary
      cd12724
      Location:446 → 537
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:554 → 634
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:629 → 690
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      24096588..24110736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173113.5 → XP_005173170.2  cytoplasmic polyadenylation element-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_005173170.2

      UniProtKB/Swiss-Prot
      Q7SXN4
      UniProtKB/TrEMBL
      A0A2R8RYC4, A0A8M3AHT9, B2GRL1
      Related
      ENSDARP00000155912.1, ENSDART00000186611.1
      Conserved Domains (4) summary
      COG0724
      Location:333 → 616
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:454 → 545
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:562 → 642
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:637 → 698
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    2. XM_009291021.4 → XP_009289296.1  cytoplasmic polyadenylation element-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_009289296.1

      UniProtKB/Swiss-Prot
      Q7SXN4
      UniProtKB/TrEMBL
      A0A2R8RYC4, A0A8M3AHT9, B2GRL1
      Conserved Domains (4) summary
      COG0724
      Location:333 → 616
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:454 → 545
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:562 → 642
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:637 → 698
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      65676..79824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXN4.1 GenPept UniProtKB/Swiss-Prot:Q7SXN4

    Gene LinkOut

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