dph1 diphthamide biosynthesis 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dph1provided by ZNC
Official Full Name: diphthamide biosynthesis 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-411
See related: Ensembl:ENSDARG00000057973 AllianceGenome:ZFIN:ZDB-GENE-050417-411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110702
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be located in cytoplasm and nucleus. Predicted to be part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 1. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (25910501..26089050, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (25975232..26153794, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G40028 (e-PCR)
- UniSTS:15646

fd12b01.x1 (e-PCR)
- UniSTS:195154

G44800 (e-PCR)
- UniSTS:105602

fi06c08.x1 (e-PCR)
- UniSTS:204434

fc66c10.x1 (e-PCR)
- UniSTS:194215

G47731 (e-PCR)
- UniSTS:108502

Z5191 (e-PCR)
- UniSTS:16118

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity	IEA Inferred from Electronic Annotation more info
contributes_to 2-(3-amino-3-carboxypropyl)histidine synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein histidyl modification to diphthamide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 2-(3-amino-3-carboxypropyl)histidine synthase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Names: S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1; diphthamide biosynthesis protein 1; diphtheria toxin resistance protein 1

NP_001017861.1

EC 2.5.1.108

XP_005157638.2

EC 2.5.1.108

XP_005157639.2

EC 2.5.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017861.1 → NP_001017861.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

See identical proteins and their annotated locations for NP_001017861.1

Status: PROVISIONAL

Source sequence(s)

BC092989

UniProtKB/Swiss-Prot

Q567W6

Related

ENSDARP00000114804.2, ENSDART00000140214.4

Conserved Domains (1) summary

pfam01866
Location:72 → 331

Diphthamide_syn; Putative diphthamide synthesis protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

25910501..26089050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157582.5 → XP_005157639.2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 isoform X2

UniProtKB/TrEMBL

A0A8M2B3R3
XM_005157581.5 → XP_005157638.2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B3R1