prkcbb protein kinase C, beta b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkcbbprovided by ZNC
Official Full Name: protein kinase C, beta bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1178
See related: Ensembl:ENSDARG00000022254 AllianceGenome:ZFIN:ZDB-GENE-040426-1178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PKC-B; Prkcb; prkcb1; zgc:63591
Summary: Predicted to enable several functions, including nuclear androgen receptor binding activity; nuclear receptor coactivator activity; and protein serine/threonine kinase activity. Acts upstream of or within blood coagulation and embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in brain; retinal neural layer; and somite border. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (35005730..35264286)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (34876222..35136544)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein kinase C beta type

Names: PKC-beta; protein kinase C, beta 1

NP_957272.1

EC 2.7.11.13

XP_005164062.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200978.1 → NP_957272.1 protein kinase C beta type

See identical proteins and their annotated locations for NP_957272.1

Status: PROVISIONAL

Source sequence(s)

BC055154

UniProtKB/Swiss-Prot

Q7SY24

Related

ENSDARP00000038918.6, ENSDART00000029451.7

Conserved Domains (4) summary

cd04026
Location:158 → 288

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:339 → 597

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05616
Location:338 → 660

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

pfam00130
Location:36 → 88

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

35005730..35264286

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164005.5 → XP_005164062.1 protein kinase C beta type isoform X1

UniProtKB/TrEMBL

A0A2R8QMW2, A0A8M2BB79

Related

ENSDARP00000155856.1, ENSDART00000181163.1

Conserved Domains (4) summary

cd04026
Location:158 → 288

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:339 → 597

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05587
Location:342 → 661

STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C

pfam00130
Location:36 → 88

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)