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    eif4g3a eukaryotic translation initiation factor 4 gamma, 3a [ Danio rerio (zebrafish) ]

    Gene ID: 566131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif4g3aprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma, 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120810-2
    See related
    Ensembl:ENSDARG00000077215 AllianceGenome:ZFIN:ZDB-GENE-120810-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif4g3
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eif4g3a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (27828830..27917424, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (27581656..27670520, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496653 Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene endothelin converting enzyme 1 Neighboring gene alkaline phosphatase, biomineralization associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development. Ohlebusch B, et al. Sci Rep, 2020 Aug 7. PMID 32770041, Free PMC Article
    2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 3
    Names
    eukaryotic translation initiation factor 4 gamma, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      27828830..27917424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689398.9 → XP_694490.5  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A140LGN9, A0A8N7UV45
      Related
      ENSDARP00000142418.1, ENSDART00000173219.2
      Conserved Domains (4) summary
      cd11559
      Location:1547 → 1682
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1348 → 1459
      MA3; MA3 domain
      pfam02854
      Location:876 → 1104
      MIF4G; MIF4G domain
      pfam11235
      Location:18 → 172
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    2. XM_009306090.4 → XP_009304365.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AXN1
      Conserved Domains (4) summary
      cd11559
      Location:1548 → 1683
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1349 → 1460
      MA3; MA3 domain
      pfam02854
      Location:877 → 1105
      MIF4G; MIF4G domain
      pfam11235
      Location:18 → 172
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    3. XM_009306089.4 → XP_009304364.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3BDQ6
      Conserved Domains (4) summary
      cd11559
      Location:1550 → 1685
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1351 → 1462
      MA3; MA3 domain
      pfam02854
      Location:879 → 1107
      MIF4G; MIF4G domain
      pfam11235
      Location:18 → 172
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    4. XM_068224352.1 → XP_068080453.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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