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    ide insulin-degrading enzyme [ Danio rerio (zebrafish) ]

    Gene ID: 561390, updated on 9-Dec-2024

    Summary

    Official Symbol
    ideprovided by ZNC
    Official Full Name
    insulin-degrading enzymeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-85
    See related
    Ensembl:ENSDARG00000075570 AllianceGenome:ZFIN:ZDB-GENE-070410-85
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162603
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ide in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (42309580..42353427)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (42183506..42226316)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kynurenine 3-monooxygenase Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene membrane-associated ring finger (C3HC4) 5 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene BTAF1 RNA polymerase II, B-TFIID transcription factor-associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Interactions

    General gene information

    Clone Names

    • MGC162603

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity  
    enables metal ion binding  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metallopeptidase activity  
    enables peptidase activity  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in mitochondrion  
    is_active_in peroxisomal matrix  

    General protein information

    Preferred Names
    insulin-degrading enzyme
    Names
    insulysin
    NP_001082994.2
    XP_005169585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089525.2 → NP_001082994.2  insulin-degrading enzyme

      Status: VALIDATED

      Source sequence(s)
      BX005050
      UniProtKB/TrEMBL
      A0A0R4IL71, A4QP10, B8JI45
      Related
      ENSDARP00000135107.1, ENSDART00000158367.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      42309580..42353427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169528.5 → XP_005169585.1  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGX2, A4QP10
      Conserved Domains (4) summary
      COG1025
      Location:24 → 939
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:53 → 191
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:217 → 395
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:401 → 682
      Peptidase_M16_M; Middle or third domain of peptidase_M16
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