crfb4 cytokine receptor family member b4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crfb4provided by ZNC
Official Full Name: cytokine receptor family member b4provided by ZNC
Primary source: ZFIN:ZDB-GENE-070905-3
See related: Ensembl:ENSDARG00000068711 AllianceGenome:ZFIN:ZDB-GENE-070905-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (15922640..16062859, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (15998950..16125589, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytokine receptor family member b4

Names: il10r2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083868.1 → NP_001077337.1 cytokine receptor family member b4 precursor

See identical proteins and their annotated locations for NP_001077337.1

Status: PROVISIONAL

Source sequence(s)

EF014954

UniProtKB/TrEMBL

A0FJH9

Related

ENSDARP00000090253.4, ENSDART00000099479.5

Conserved Domains (2) summary

pfam09294
Location:118 → 213

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:25 → 106

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...