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    amy2al1 amylase alpha 2A-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amy2al1provided by ZNC
    Official Full Name
    amylase alpha 2A-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1606
    See related
    Ensembl:ENSDARG00000030357 AllianceGenome:ZFIN:ZDB-GENE-040426-1606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66313
    Summary
    Predicted to enable alpha-amylase activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be active in extracellular space. Is expressed in digestive system; endocrine system; gut; lens; and pancreas. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See amy2al1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43863743..43886997)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43749948..43773236)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 1Ca Neighboring gene uncharacterized LOC137488137 Neighboring gene dr1-associated corepressor Neighboring gene AHA1, activator of heat shock protein ATPase homolog 1b Neighboring gene uncharacterized LOC137488139 Neighboring gene mutS homolog 4 Neighboring gene kinectin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus. Jiang M, et al. Microb Biotechnol, 2020 Jul. PMID 32364684, Free PMC Article
    2. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC66313

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AmyAc_bac_euk_AmyA and Aamy_C domain-containing protein; amyAc_bac_euk_AmyA and Aamy_C domain-containing protein
    NP_956722.2
    XP_005158947.1
    XP_017207095.1
    XP_068070442.1
    XP_068070443.1
    XP_068070444.1
    XP_068070445.1
    XP_068070446.1
    XP_068070447.1
    XP_068070448.1
    XP_068070449.1
    XP_068070450.1
    XP_068070451.1
    XP_068070452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200428.2 → NP_956722.2  AmyAc_bac_euk_AmyA and Aamy_C domain-containing protein precursor

      Status: VALIDATED

      Source sequence(s)
      BX465227
      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9
      Related
      ENSDARP00000112576.1, ENSDART00000134272.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      43863743..43886997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214348.1 → XP_068070449.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    2. XM_068214349.1 → XP_068070450.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    3. XM_068214351.1 → XP_068070452.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    4. XM_068214344.1 → XP_068070445.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X1

      UniProtKB/TrEMBL
      Q7SYK9

    5. XM_068214346.1 → XP_068070447.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    6. XM_068214341.1 → XP_068070442.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X1

      UniProtKB/TrEMBL
      Q7SYK9

    7. XM_068214345.1 → XP_068070446.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    8. XM_068214350.1 → XP_068070451.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    9. XM_068214342.1 → XP_068070443.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X1

      UniProtKB/TrEMBL
      Q7SYK9

    10. XM_017351606.3 → XP_017207095.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9
      Related
      ENSDARP00000137839.1, ENSDART00000167214.2
      Conserved Domains (3) summary
      cd11317
      Location:25 → 417
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:424 → 511
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 315
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    11. XM_068214343.1 → XP_068070444.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X1

      UniProtKB/TrEMBL
      Q7SYK9

    12. XM_068214347.1 → XP_068070448.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9

    13. XM_005158890.5 → XP_005158947.1  amyAc_bac_euk_AmyA and Aamy_C domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_005158947.1

      UniProtKB/TrEMBL
      A0A0R4IST0, A0A8M2B5V6, Q7SYK9
      Conserved Domains (3) summary
      cd11317
      Location:25 → 417
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:424 → 511
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 315
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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