cpm carboxypeptidase M [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpmprovided by ZNC
Official Full Name: carboxypeptidase Mprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-191
See related: Ensembl:ENSDARG00000011769 AllianceGenome:ZFIN:ZDB-GENE-041210-191
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7143022; zgc:110307; im:7143022l; si:dkey-11p6.1
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Is expressed in nervous system; neural tube; otic vesicle; and trunk vasculature. Orthologous to human CPM (carboxypeptidase M). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (23740654..23759192, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (24019679..24038263, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj06h10.y1 (e-PCR)
- UniSTS:198437

G40950 (e-PCR)
- UniSTS:49349

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carboxypeptidase M

NP_001017591.1

EC 3.4.17.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017591.1 → NP_001017591.1 carboxypeptidase M precursor

See identical proteins and their annotated locations for NP_001017591.1

Status: PROVISIONAL

Source sequence(s)

BC092863

UniProtKB/TrEMBL

Q568G8

Related

ENSDARP00000007770.5, ENSDART00000014685.7

Conserved Domains (2) summary

cd03866
Location:17 → 309

M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup

cd11308
Location:313 → 393

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain