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    hbae3 hemoglobin alpha embryonic-3 [ Danio rerio (zebrafish) ]

    Gene ID: 30601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hbae3provided by ZNC
    Official Full Name
    hemoglobin alpha embryonic-3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990706-3
    See related
    Ensembl:ENSDARG00000079305 AllianceGenome:ZFIN:ZDB-GENE-990706-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    globin; fb57a06; zgc:86867; wu:fb57a06; si:by119c3.4; si:ch211-5k11.15
    Summary
    Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to act upstream of or within oxygen transport. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in hematopoietic cell; hematopoietic system; mesoderm; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hbae3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55146590..55147767, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54891994..54893165, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin, beta embryonic 1.3 Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Two-color fluorescent in situ hybridization using chromogenic substrates in zebrafish. Schumacher JA, et al. Biotechniques, 2014 Nov. PMID 25391914, Free PMC Article
    2. Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells. Petrova NV, et al. Biochimie, 2021 Feb. PMID 33321129
    3. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Mercurio S, et al. Haematologica, 2015 Jun. PMID 25795718, Free PMC Article
    4. Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters. Kovina AP, et al. Mol Biol Evol, 2017 Jun 1. PMID 28333290
    5. Characterization of embryonic globin genes of the zebrafish. Brownlie A, et al. Dev Biol, 2003 Mar 1. PMID 12618133

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to haptoglobin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of haptoglobin-hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin alpha embryonic-3
    Names
    dZ118J2.11 (novel alpha-globin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183066.3 → NP_898889.2  hemoglobin alpha embryonic-3

      See identical proteins and their annotated locations for NP_898889.2

      Status: VALIDATED

      Source sequence(s)
      CU464181
      UniProtKB/TrEMBL
      A0A8N7XJ27, F1Q6U4, Q6IQA3, Q7ZYZ4
      Related
      ENSDARP00000103718.2, ENSDART00000109016.2
      Conserved Domains (1) summary
      cd08927
      Location:3 → 143
      Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      55146590..55147767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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