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    usp2a ubiquitin specific peptidase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 494031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp2aprovided by ZNC
    Official Full Name
    ubiquitin specific peptidase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-59
    See related
    Ensembl:ENSDARG00000020107 AllianceGenome:ZFIN:ZDB-GENE-041212-59
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92134
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination; proteolysis; and rhythmic process. Predicted to be active in cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See usp2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20900627..20939558, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20964895..21003867, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene GTPase IMAP family member 9 Neighboring gene tubulin folding cofactor E-like a Neighboring gene alpha-2-macroglobulin-like protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas. Boustani MR, et al. J Neurol Sci, 2016 Apr 15. PMID 27000259
    2. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. Rodius S, et al. BMC Genomics, 2014 Oct 3. PMID 25280539, Free PMC Article
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of USP2a in brain tissue from primary glioma patients was correlated with poor survival.
      Title: Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 2a
    NP_001008574.2
    XP_005157570.1
    XP_005157571.1
    XP_005157572.1
    XP_005157573.1
    XP_017206440.1
    XP_021337071.1
    XP_068069639.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008574.2 → NP_001008574.2  ubiquitin carboxyl-terminal hydrolase 2a

      Status: VALIDATED

      Source sequence(s)
      BX548078
      UniProtKB/TrEMBL
      A0A8M1N3I7, F1R2P1
      Related
      ENSDARP00000119800.1, ENSDART00000134053.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20900627..20939558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213538.1 → XP_068069639.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4B5

    2. XM_005157514.5 → XP_005157571.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X1

      See identical proteins and their annotated locations for XP_005157571.1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230 → 559
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_021481396.2 → XP_021337071.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230 → 559
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_005157515.5 → XP_005157572.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4B5
      Conserved Domains (2) summary
      cd02674
      Location:231 → 559
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:229 → 558
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_017350951.3 → XP_017206440.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230 → 559
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. XM_005157513.5 → XP_005157570.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X1

      See identical proteins and their annotated locations for XP_005157570.1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230 → 559
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. XM_005157516.5 → XP_005157573.1  ubiquitin carboxyl-terminal hydrolase 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M2B3N0
      Conserved Domains (2) summary
      cd02674
      Location:62 → 391
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:60 → 390
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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