U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lpcat2 lysophosphatidylcholine acyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553683, updated on 9-Dec-2024

    Summary

    Official Symbol
    lpcat2provided by ZNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-229
    See related
    Ensembl:ENSDARG00000053010 AllianceGenome:ZFIN:ZDB-GENE-050522-229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aytl1; zgc:112165
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and 1-alkylglycerophosphocholine O-acetyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPCAT2 (lysophosphatidylcholine acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See lpcat2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (35386257..35408332, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (35114575..35136890, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 4 Neighboring gene solute carrier family 6 member 2 Neighboring gene uncharacterized LOC101885114 Neighboring gene matrix metallopeptidase 2 Neighboring gene uncharacterized LOC110439935 Neighboring gene iroquois homeobox 6a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC112165

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables plasmalogen synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase 2
    Names
    1-AGP acyltransferase 11
    1-AGPAT 11
    1-acylglycerol-3-phosphate O-acyltransferase 11
    1-acylglycerophosphocholine O-acyltransferase
    1-alkenylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPC acyltransferase 2
    LPCAT-2
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyltransferase like 1
    lyso-PAF acetyltransferase
    lysoPAFAT
    lysoPC acyltransferase 2
    NP_001018492.1
    XP_005169036.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020656.1NP_001018492.1  lysophosphatidylcholine acyltransferase 2

      See identical proteins and their annotated locations for NP_001018492.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095679
      UniProtKB/Swiss-Prot
      Q502J0
      Related
      ENSDARP00000069449.3, ENSDART00000074963.4
      Conserved Domains (5) summary
      cd07991
      Location:98309
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:49297
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:418473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:415473
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:316406
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      35386257..35408332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168979.5XP_005169036.1  lysophosphatidylcholine acyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG99, F1Q8S6
      Related
      ENSDARP00000111397.1, ENSDART00000128334.4
      Conserved Domains (5) summary
      cd07991
      Location:98309
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:49297
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:418473
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:415473
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:316406
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...