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    wars1 tryptophanyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wars1provided by ZNC
    Official Full Name
    tryptophanyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1742
    See related
    Ensembl:ENSDARG00000104659 AllianceGenome:ZFIN:ZDB-GENE-040426-1742
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wars; TrpRS; zgc:73274
    Summary
    Predicted to enable ATP binding activity and tryptophan-tRNA ligase activity. Acts upstream of or within auditory receptor cell development and embryonic neurocranium morphogenesis. Is expressed in several structures, including adaxial cell; brain; digestive system; eye; and muscle. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See wars1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003335559.1 (1..2027)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335559.1 (1..2027)

    NW_003335559.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution. Nakamoto T, et al. Sci Rep, 2016 Apr 20. PMID 27094087, Free PMC Article
    2. Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function. Lin SJ, et al. Hum Mutat, 2022 Oct. PMID 35815345
    3. WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly. Bögershausen N, et al. Hum Mutat, 2022 Oct. PMID 35790048
    4. Induction of endoplasmic reticulum stress markers in an acromegaly model. Elbialy A, et al. J Cell Biochem, 2022 Sep. PMID 35734917
    5. Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Accogli A, et al. Genet Med, 2023 Nov. PMID 37454282, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73274

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    NP_957066.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200772.1 → NP_957066.1  tryptophan--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_957066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059603
      UniProtKB/Swiss-Prot
      Q6PBS3
      Related
      ENSDARP00000133255.1, ENSDART00000166498.2
      Conserved Domains (3) summary
      PLN02486
      Location:78 → 460
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:7 → 56
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      TIGR00233
      Location:147 → 456
      trpS; tryptophanyl-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NW_003335559.1 Reference GRCz11 Primary Assembly

      Range
      1..2027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PBS3.1 GenPept UniProtKB/Swiss-Prot:Q6PBS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.