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    islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    islr2provided by ZNC
    Official Full Name
    immunoglobulin superfamily containing leucine-rich repeat 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-95
    See related
    Ensembl:ENSDARG00000051875 AllianceGenome:ZFIN:ZDB-GENE-050320-95
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101901
    Summary
    Acts upstream of or within retinal ganglion cell axon guidance. Is expressed in nervous system. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See islr2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22635166..22639133, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (22537618..22541631, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882374 Neighboring gene uncharacterized LOC137489297 Neighboring gene uncharacterized LOC110438386 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene Usher syndrome 1C Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A cell surface interaction network of neural leucine-rich repeat receptors. Söllner C, et al. Genome Biol, 2009. PMID 19765300, Free PMC Article
    2. The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Panza P, et al. Neural Dev, 2015 Oct 22. PMID 26492970, Free PMC Article
    3. Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Garaffo G, et al. Front Endocrinol (Lausanne), 2013. PMID 24427155, Free PMC Article
    4. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Gao X, et al. Cell Rep, 2015 Jul 28. PMID 26190107
    5. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin superfamily containing leucine-rich repeat protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013523.1 → NP_001013541.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

      See identical proteins and their annotated locations for NP_001013541.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090831
      Related
      ENSDARP00000068073.4, ENSDART00000073583.5
      Conserved Domains (6) summary
      smart00082
      Location:183 → 221
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:252 → 345
      IG_like; Immunoglobulin like
      cd00116
      Location:47 → 184
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:35 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:102 → 161
      LRR_8; Leucine rich repeat
      cl11960
      Location:256 → 345
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      22635166..22639133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395203.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      465398..469365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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