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    lpar2b lysophosphatidic acid receptor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 567956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpar2bprovided by ZNC
    Official Full Name
    lysophosphatidic acid receptor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-99
    See related
    Ensembl:ENSDARG00000042561 AllianceGenome:ZFIN:ZDB-GENE-051120-99
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123246
    Summary
    Enables lysophosphatidic acid receptor activity. Acts upstream of or within angiogenesis and posterior lateral line development. Predicted to be located in cell surface and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in axis; posterior lateral line neuromast; posterior lateral line primordium; and yolk syncytial layer. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lpar2b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (59191945..59216197, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (58415065..58439317, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene wu:fk65c09 Neighboring gene calmodulin-regulated spectrin-associated protein 3 Neighboring gene A kinase (PRKA) anchor protein 8-like Neighboring gene multivesicular body subunit 12A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis. Lin KH, et al. Sci Rep, 2016 May 31. PMID 27244685, Free PMC Article
    2. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Nakanaga K, et al. J Biochem, 2014 Apr. PMID 24451492
    3. Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish. Wang X, et al. Front Mol Neurosci, 2018. PMID 29479307, Free PMC Article
    4. Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish. Frisca F, et al. Sci Rep, 2016 Nov 24. PMID 27883058, Free PMC Article
    5. Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. Yukiura H, et al. J Biol Chem, 2011 Dec 23. PMID 21971049, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation.
      Title: Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123246

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320133.1 → NP_001307062.1  lysophosphatidic acid receptor 2b

      Status: VALIDATED

      Source sequence(s)
      CABZ01118680, CABZ01118681, CABZ01118682, CABZ01118684
      UniProtKB/TrEMBL
      A0A8M2BIF4, A0A8M9QCS0, F1Q734
      Related
      ENSDARP00000062425.5, ENSDART00000062426.6
      Conserved Domains (1) summary
      cd15342
      Location:29 → 300
      7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      59191945..59216197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475649.2 → XP_021331324.1  lysophosphatidic acid receptor 2b isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1Z5, A0A8M9QCS0
      Conserved Domains (1) summary
      cd15342
      Location:29 → 300
      7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_068220552.1 → XP_068076653.1  lysophosphatidic acid receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIF4, A0A8M9QCS0, F1Q734

    3. XM_005171058.5 → XP_005171115.1  lysophosphatidic acid receptor 2b isoform X1

      See identical proteins and their annotated locations for XP_005171115.1

      UniProtKB/TrEMBL
      A0A8M2BIF4, A0A8M9QCS0, F1Q734
      Conserved Domains (1) summary
      cd15342
      Location:29 → 300
      7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_068220558.1 → XP_068076659.1  lysophosphatidic acid receptor 2b isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1Z5, A0A8M9QCS0

    5. XM_068220546.1 → XP_068076647.1  lysophosphatidic acid receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIF4, A0A8M9QCS0, F1Q734

    6. XM_068220540.1 → XP_068076641.1  lysophosphatidic acid receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIF4, A0A8M9QCS0, F1Q734

    RNA

    1. XR_011011357.1 RNA Sequence

    2. XR_011011356.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037694.1: Suppressed sequence

      Description
      NM_001037694.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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