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    slc12a7b solute carrier family 12 member 7b [ Danio rerio (zebrafish) ]

    Gene ID: 567667, updated on 27-Dec-2024

    Summary

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    Official Symbol
    slc12a7bprovided by ZNC
    Official Full Name
    solute carrier family 12 member 7bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-61
    See related
    Ensembl:ENSDARG00000062058 AllianceGenome:ZFIN:ZDB-GENE-030829-61
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb734; si:dkeyp-106g6.1
    Summary
    Predicted to enable potassium:chloride symporter activity. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including cranial ganglion; fin; myotome; neural tube; and sensory system. Orthologous to human SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc12a7b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (39778645..39885802, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (39890801..39997951, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene receptor-type tyrosine-protein phosphatase eta Neighboring gene glucose-fructose oxidoreductase domain containing 1 Neighboring gene uncharacterized LOC572443 Neighboring gene uncharacterized LOC100004848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development. Lanni JS, et al. Dev Biol, 2019 Dec 15. PMID 31472116, Free PMC Article
    2. Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. Matos-Cruz V, et al. PLoS One, 2011. PMID 21966429, Free PMC Article
    3. Reverse genetic analysis of neurogenesis in the zebrafish retina. Pujic Z, et al. Dev Biol, 2006 May 15. PMID 16603149
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 6; solute carrier family 12 member 7
    Names
    bipolin
    solute carrier family 12 (potassium/chloride transporter), member 7b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      39778645..39885802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162914.5 → XP_005162971.1  solute carrier family 12 member 7 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B9W9
      Conserved Domains (3) summary
      TIGR00930
      Location:58 → 1096
      2a30; K-Cl cotransporter
      pfam03522
      Location:724 → 1096
      SLC12; Solute carrier family 12
      cl00456
      Location:182 → 319
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_005162913.5 → XP_005162970.1  solute carrier family 12 member 7 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BA74
      Conserved Domains (3) summary
      TIGR00930
      Location:58 → 1101
      2a30; K-Cl cotransporter
      pfam03522
      Location:724 → 1101
      SLC12; Solute carrier family 12
      cl00456
      Location:182 → 319
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_005162911.5 → XP_005162968.1  solute carrier family 12 member 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B9W4
      Related
      ENSDARP00000083665.6, ENSDART00000089232.6
      Conserved Domains (3) summary
      TIGR00930
      Location:58 → 1133
      2a30; K-Cl cotransporter
      pfam03522
      Location:724 → 1133
      SLC12; Solute carrier family 12
      cl00456
      Location:182 → 319
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_005162910.5 → XP_005162967.1  solute carrier family 12 member 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA14
      Conserved Domains (3) summary
      TIGR00930
      Location:58 → 1138
      2a30; K-Cl cotransporter
      pfam03522
      Location:724 → 978
      SLC12; Solute carrier family 12
      cl00456
      Location:182 → 319
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_068217266.1 → XP_068073367.1  solute carrier family 12 member 7 isoform X8

      Related
      ENSDARP00000115749.1, ENSDART00000134251.3

    6. XM_068217265.1 → XP_068073366.1  solute carrier family 12 member 7 isoform X7

    7. XM_690968.9 → XP_696060.6  solute carrier family 12 member 7 isoform X3

      UniProtKB/TrEMBL
      A0A8N7TBP4
      Conserved Domains (3) summary
      TIGR00930
      Location:39 → 1119
      2a30; K-Cl cotransporter
      pfam03522
      Location:705 → 959
      SLC12; Solute carrier family 12
      cl00456
      Location:163 → 300
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_005162915.5 → XP_005162972.1  solute carrier family 12 member 7 isoform X6

      UniProtKB/TrEMBL
      A0A8M2B9Y8
      Conserved Domains (3) summary
      TIGR00930
      Location:14 → 1094
      2a30; K-Cl cotransporter
      pfam03522
      Location:680 → 934
      SLC12; Solute carrier family 12
      cl00456
      Location:138 → 275
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version

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