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    angptl2a angiopoietin-like 2a [ Danio rerio (zebrafish) ]

    Gene ID: 569092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    angptl2aprovided by ZNC
    Official Full Name
    angiopoietin-like 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080721-15
    See related
    Ensembl:ENSDARG00000024030 AllianceGenome:ZFIN:ZDB-GENE-080721-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    angptl2b; zgc:194138; zgc:194145
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See angptl2a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (4797329..4829254)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (4372677..4403839)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cystatin-B-like Neighboring gene uncharacterized LOC110439800 Neighboring gene ras-specific guanine nucleotide-releasing factor RalGPS1-like Neighboring gene uncharacterized LOC137495547 Neighboring gene zinc finger and BTB domain containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030230.1 → NP_001025401.1  angiopoietin-related protein 2a precursor

      See identical proteins and their annotated locations for NP_001025401.1

      Status: PROVISIONAL

      Source sequence(s)
      AB197679
      UniProtKB/TrEMBL
      B3DGJ4, Q4LES0
      Related
      ENSDARP00000067598.4, ENSDART00000067599.7
      Conserved Domains (3) summary
      cd00087
      Location:305 → 519
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:119 → 215
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam08961
      Location:50 → 147
      DUF1875; Domain of unknown function (DUF1875)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      4797329..4829254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168602.5 → XP_005168659.1  angiopoietin-related protein 2a isoform X1

      See identical proteins and their annotated locations for XP_005168659.1

      UniProtKB/TrEMBL
      B3DGJ4, Q4LES0
      Conserved Domains (3) summary
      cd00087
      Location:305 → 519
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:119 → 215
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam08961
      Location:50 → 147
      DUF1875; Domain of unknown function (DUF1875)
    Nucleotide Protein
    Heading Accession and Version

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