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    ogt.1 O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 337685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ogt.1provided by ZNC
    Official Full Name
    O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9631
    See related
    Ensembl:ENSDARG00000105243 AllianceGenome:ZFIN:ZDB-GENE-030131-9631
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ogt; fm81g08; wu:fc12b01; wu:fm81g08
    Summary
    Enables protein N-acetylglucosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Is expressed in brain; caudal fin; and trunk. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ogt.1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (14725355..14745660, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14419100..14440097, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene germ cell nuclear acidic peptidase Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 Neighboring gene uncharacterized LOC137487515 Neighboring gene uncharacterized LOC101882685 Neighboring gene FH2 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis. Sohn KC, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188232
    2. OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. Hrit J, et al. Elife, 2018 Oct 16. PMID 30325306, Free PMC Article
    3. Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Park J, et al. J Neuroinflammation, 2023 Nov 9. PMID 37946213, Free PMC Article
    4. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
    5. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. Webster DM, et al. BMC Dev Biol, 2009 Apr 21. PMID 19383152, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identify a TET1 domain that is necessary and sufficient for binding to OGT and report a point mutation that disrupts the TET1-OGT interaction.show that this interaction is necessary for TET1 to rescue hematopoetic stem cell production in tet mutant zebrafish embryos, suggesting that OGT promotes TET1's function during development.
      Title: OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.
    2. Overexpression of Ogt delayed epiboly and caused a severe disorganization of the microtubule and actin based cytoskeleton in the extra-embryonic yolk syncytial layer.
      Title: O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development.
    3. Developmental regulation of zOGT transcriptional variants generated by alternative splicing and characterization of their OGT activities of protein O-GlcNAcylation.
      Title: Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Names
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1
    O-linked N-acetylglucosamine transferase
    copy I
    ogta
    NP_001017359.1
    NP_001018115.1
    NP_001018116.1
    NP_001018117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017359.1 → NP_001017359.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

      See identical proteins and their annotated locations for NP_001017359.1

      Status: PROVISIONAL

      Source sequence(s)
      AY696178
      UniProtKB/TrEMBL
      A0A0R4IVJ0, A0A8M1QLF2, Q5GA13
      Related
      ENSDARP00000137847.1, ENSDART00000159101.2
      Conserved Domains (7) summary
      COG0457
      Location:204 → 461
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:293 → 321
      TPR; TPR repeat [structural motif]
      cd15832
      Location:290 → 322
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:89 → 122
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:213 → 246
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:556 → 1038
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:276 → 430
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. NM_001018105.1 → NP_001018115.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

      See identical proteins and their annotated locations for NP_001018115.1

      Status: PROVISIONAL

      Source sequence(s)
      AY696179
      UniProtKB/TrEMBL
      A0A8M2B3B2, Q5GA12
      Related
      ENSDARP00000136328.1, ENSDART00000171285.2
      Conserved Domains (7) summary
      COG0457
      Location:194 → 451
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:283 → 311
      TPR; TPR repeat [structural motif]
      cd15832
      Location:280 → 312
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:79 → 112
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:203 → 236
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:546 → 1028
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:266 → 420
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    3. NM_001018106.1 → NP_001018116.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 3

      See identical proteins and their annotated locations for NP_001018116.1

      Status: PROVISIONAL

      Source sequence(s)
      AY696180
      UniProtKB/TrEMBL
      A0A0R4IVJ0, A0A8M1QLF2, Q5GA11
      Related
      ENSDARP00000131176.1, ENSDART00000163199.2
      Conserved Domains (7) summary
      COG0457
      Location:204 → 461
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:293 → 321
      TPR; TPR repeat [structural motif]
      cd15832
      Location:290 → 322
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:89 → 122
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:213 → 246
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:556 → 1022
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:276 → 430
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    4. NM_001018107.1 → NP_001018117.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 4

      See identical proteins and their annotated locations for NP_001018117.1

      Status: PROVISIONAL

      Source sequence(s)
      AY696181
      UniProtKB/TrEMBL
      A0A8M2B3B2, Q5GA10
      Related
      ENSDARP00000141417.1, ENSDART00000170623.2
      Conserved Domains (7) summary
      COG0457
      Location:194 → 451
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:283 → 311
      TPR; TPR repeat [structural motif]
      cd15832
      Location:280 → 312
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:79 → 112
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:203 → 236
      TPR_17; Tetratricopeptide repeat
      pfam13844
      Location:546 → 1012
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:266 → 420
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      14725355..14745660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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