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    parp2 poly (ADP-ribose) polymerase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100007906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    parp2provided by ZNC
    Official Full Name
    poly (ADP-ribose) polymerase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031113-6
    See related
    Ensembl:ENSDARG00000079202 AllianceGenome:ZFIN:ZDB-GENE-031113-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb996; adprtl2
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in double-strand break repair and protein poly-ADP-ribosylation. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus. Is expressed in brain; head; and proliferative region. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See parp2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37836826..37846849)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37854732..37865074)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 39U, member 1 Neighboring gene methyltransferase like 17 Neighboring gene ribonuclease P RNA component H1 Neighboring gene si:ch211-284o19.8 Neighboring gene zgc:66427

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro. Lu C, et al. Ecotoxicol Environ Saf, 2021 Jan 15. PMID 33120273
    2. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly [ADP-ribose] polymerase 2
    Names
    ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
    poly (ADP-ribose) polymerase family, member 2
    NP_001191199.1
    XP_021334004.1
    XP_021334005.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204270.1 → NP_001191199.1  poly [ADP-ribose] polymerase 2

      Status: VALIDATED

      Source sequence(s)
      AL954692
      UniProtKB/TrEMBL
      A0A8M1P2P6, F1QAF7
      Related
      ENSDARP00000103156.4, ENSDART00000113337.4
      Conserved Domains (4) summary
      cd08003
      Location:174 → 276
      WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
      cd01437
      Location:296 → 641
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:430 → 642
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam02825
      Location:23 → 86
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37836826..37846849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478330.2 → XP_021334005.1  poly [ADP-ribose] polymerase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIR2
      Conserved Domains (2) summary
      pfam02825
      Location:23 → 86
      WWE; WWE domain
      cl27333
      Location:98 → 645
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    2. XM_021478329.2 → XP_021334004.1  poly [ADP-ribose] polymerase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIR2
      Related
      ENSDARP00000118376.1, ENSDART00000143203.3
      Conserved Domains (2) summary
      pfam02825
      Location:23 → 86
      WWE; WWE domain
      cl27333
      Location:98 → 645
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394505.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      19272..28872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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