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    ptprb protein tyrosine phosphatase receptor type b [ Danio rerio (zebrafish) ]

    Gene ID: 100149130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptprbprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101108-3
    See related
    Ensembl:ENSDARG00000076624 AllianceGenome:ZFIN:ZDB-GENE-101108-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    R-PTP-beta
    Summary
    Predicted to enable cadherin binding activity. Acts upstream of or within blood vessel development. Predicted to be located in membrane. Predicted to be part of receptor complex. Is expressed in oocyte and vasculature. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ptprb in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (74271064..74367949, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (72814649..72914114, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:cabz01069012.2 Neighboring gene RAB21, member RAS oncogene family Neighboring gene protein tyrosine phosphatase receptor type R Neighboring gene tripartite motif containing 24 Neighboring gene zmp:0000001020 Neighboring gene si:cabz01083838.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ve-ptp modulates vascular integrity by promoting adherens junction maturation. Carra S, et al. PLoS One, 2012. PMID 23251467, Free PMC Article
    2. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Wu Y, et al. Orphanet J Rare Dis, 2020 Apr 22. PMID 32321550, Free PMC Article
    3. Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Chen K, et al. Exp Ther Med, 2018 Dec. PMID 30542405, Free PMC Article
    4. Identification of ACTA2 as a Key Contributor to Venous Malformation. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34858981, Free PMC Article
    5. In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Chen K, et al. Drug Des Devel Ther, 2020. PMID 32801645, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase beta
    Names
    zve-ptp
    NP_001303656.1
    XP_009297813.1
    XP_021330573.1
    XP_021330574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316727.1 → NP_001303656.1  receptor-type tyrosine-protein phosphatase beta precursor

      Status: VALIDATED

      Source sequence(s)
      CABZ01062511, CABZ01062520, CN502295, DT078862, EH569174, LO018023, LO018024
      UniProtKB/TrEMBL
      A0A0R4ITJ9, A0A1L1QZQ6, A0A8M1P743
      Related
      ENSDARP00000143178.1, ENSDART00000174199.2
      Conserved Domains (4) summary
      cd00047
      Location:1637 → 1867
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:113 → 199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:823 → 896
      fn3; Fibronectin type III domain
      cl21522
      Location:1001 → 1081
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      74271064..74367949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299538.3 → XP_009297813.1  receptor-type tyrosine-protein phosphatase beta isoform X2

      UniProtKB/TrEMBL
      A0A8M3B8C0
      Conserved Domains (3) summary
      smart00194
      Location:1521 → 1779
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1549 → 1779
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:292 → 365
      fn3; Fibronectin type III domain

    2. XM_021474898.2 → XP_021330573.1  receptor-type tyrosine-protein phosphatase beta isoform X1

      UniProtKB/TrEMBL
      A0A0R4ITJ9, A0A1L1QZQ6, A0A8M1P743
      Conserved Domains (4) summary
      cd00047
      Location:1637 → 1867
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:113 → 199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:823 → 896
      fn3; Fibronectin type III domain
      cl21522
      Location:1001 → 1081
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_021474899.2 → XP_021330574.1  receptor-type tyrosine-protein phosphatase beta isoform X1

      UniProtKB/TrEMBL
      A0A0R4ITJ9, A0A1L1QZQ6, A0A8M1P743
      Conserved Domains (4) summary
      cd00047
      Location:1637 → 1867
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:113 → 199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:823 → 896
      fn3; Fibronectin type III domain
      cl21522
      Location:1001 → 1081
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199134.1: Suppressed sequence

      Description
      NM_001199134.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from frog (X.tr): ptprb (GeneID:100192375).
    Nucleotide Protein Strain
    Heading Accession and Version

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