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    eps8a EGFR pathway substrate 8a, signaling adaptor [ Danio rerio (zebrafish) ]

    Gene ID: 393212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eps8aprovided by ZNC
    Official Full Name
    EGFR pathway substrate 8a, signaling adaptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-871
    See related
    Ensembl:ENSDARG00000102128 AllianceGenome:ZFIN:ZDB-GENE-040426-871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eps8; zgc:56041
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eps8a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (151505..178510, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (90899..117908)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene TANK-binding kinase 1 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene protein tyrosine phosphatase receptor type O

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56041

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8a
    Names
    epidermal growth factor receptor pathway substrate 8
    epidermal growth factor receptor pathway substrate 8a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200242.1 → NP_956536.1  epidermal growth factor receptor kinase substrate 8a

      See identical proteins and their annotated locations for NP_956536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047814
      UniProtKB/TrEMBL
      A0A8M3ARA8, Q7ZUV6
      Conserved Domains (3) summary
      cd09540
      Location:702 → 766
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:481 → 533
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:48 → 178
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      151505..178510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219562.1 → XP_068075663.1  epidermal growth factor receptor kinase substrate 8a isoform X7

      UniProtKB/TrEMBL
      A0A8M6YXX0

    2. XM_068219556.1 → XP_068075657.1  epidermal growth factor receptor kinase substrate 8a isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z5A1

    3. XM_005168496.4 → XP_005168553.1  epidermal growth factor receptor kinase substrate 8a isoform X8

      UniProtKB/TrEMBL
      A0A0R4IID9, A0A0R4IIJ9, A0A8M2BFT5, A0A8M3ARA8, F1QMN2
      Related
      ENSDARP00000133193.2, ENSDART00000171333.2
      Conserved Domains (3) summary
      cd09540
      Location:702 → 766
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:481 → 533
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:48 → 178
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_068219560.1 → XP_068075661.1  epidermal growth factor receptor kinase substrate 8a isoform X5

      UniProtKB/TrEMBL
      A0A8M3AR20

    5. XM_068219559.1 → XP_068075660.1  epidermal growth factor receptor kinase substrate 8a isoform X4

      UniProtKB/TrEMBL
      A0A8M3B1E2

    6. XM_068219558.1 → XP_068075659.1  epidermal growth factor receptor kinase substrate 8a isoform X3

      UniProtKB/TrEMBL
      A0A8M3ARA4

    7. XM_068219557.1 → XP_068075658.1  epidermal growth factor receptor kinase substrate 8a isoform X2

      UniProtKB/TrEMBL
      A0A8M3B8N1

    8. XM_068219561.1 → XP_068075662.1  epidermal growth factor receptor kinase substrate 8a isoform X6

      UniProtKB/TrEMBL
      A0A8M3B8N5

    9. XM_009299922.4 → XP_009298197.1  epidermal growth factor receptor kinase substrate 8a isoform X9

      See identical proteins and their annotated locations for XP_009298197.1

      UniProtKB/TrEMBL
      A0A8M3AYF2, A0A8M3B1E6
      Conserved Domains (3) summary
      cd09540
      Location:755 → 819
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:514 → 566
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:48 → 178
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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