bnip3 BCL2 interacting protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bnip3provided by ZNC
Official Full Name: BCL2 interacting protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8060
See related: Ensembl:ENSDARG00000099961 AllianceGenome:ZFIN:ZDB-GENE-030131-8060
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nip3c; fj49c01; wu:fj49c01; zgc:198406
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in mitochondrial outer membrane permeabilization and positive regulation of programmed cell death. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane and mitochondrial envelope. Predicted to be active in endoplasmic reticulum; mitochondrial outer membrane; and nuclear envelope. Is expressed in liver. Orthologous to human BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (41697941..41713763)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (40534007..40548065)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish nip3a was induced by hypoxia. p53 mutation/knockdown enhanced nip3a expression under hypoxia resulted in cell death enhancement in p53 mutant embryos.
Title: p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Names: BCL2/adenovirus E1B interacting protein 3; Bcl-2/adenovirus E1B 19kD interaction protein 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012245.1 → NP_001012245.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

See identical proteins and their annotated locations for NP_001012245.1

Status: PROVISIONAL

Source sequence(s)

AY424950

UniProtKB/TrEMBL

Q5VK50

Related

ENSDARP00000140152.2, ENSDART00000162302.2

Conserved Domains (1) summary

pfam06553
Location:2 → 183

BNIP3; BNIP3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

41697941..41713763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005172968.5 → XP_005173025.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1

UniProtKB/TrEMBL

A0A8M2BKA1

Conserved Domains (1) summary

pfam06553
Location:2 → 195

BNIP3; BNIP3