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    crsp7 cofactor required for Sp1 transcriptional activation, subunit 7 [ Danio rerio (zebrafish) ]

    Gene ID: 406332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crsp7provided by ZNC
    Official Full Name
    cofactor required for Sp1 transcriptional activation, subunit 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2005
    See related
    Ensembl:ENSDARG00000105102 AllianceGenome:ZFIN:ZDB-GENE-040426-2005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    med26; zgc:55993; wu:fe06c07; wu:fi75a09
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See crsp7 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24559475..24565237, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24903824..24909586, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487819 Neighboring gene calponin 2 Neighboring gene CREB regulated transcription coactivator 1a Neighboring gene Growth differentiation factor-15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 26
    Names
    CRSP complex subunit 7
    CRSP70
    mediator complex subunit 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213059.1 → NP_998224.1  mediator of RNA polymerase II transcription subunit 26

      See identical proteins and their annotated locations for NP_998224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045849
      UniProtKB/Swiss-Prot
      Q7ZVI4, Q90YL3
      Related
      ENSDART00000184507.1
      Conserved Domains (3) summary
      smart00509
      Location:12 → 86
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:405 → 587
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:175 → 404
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24559475..24565237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90YL3.2 GenPept UniProtKB/Swiss-Prot:Q90YL3

    Gene LinkOut

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