zbtb16a zinc finger and BTB domain containing 16a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zbtb16aprovided by ZNC
Official Full Name: zinc finger and BTB domain containing 16aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1989
See related: Ensembl:ENSDARG00000007184 AllianceGenome:ZFIN:ZDB-GENE-030131-1989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZNF145; zbtb16; zgc:55675; wu:fb93g12; wu:fc07c10
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of type I interferon production and regulation of neurogenesis. Located in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (23163987..23307796, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (23123746..23271211, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
Title: Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
the results provide strong evidence that zbtb16a loss of function is associated with a partially penetrant severe cardiac development defect.
Title: A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.
Although zbtb16a and zbtb16b are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response.
Title: Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd02e12.x1 (e-PCR)
- UniSTS:204046

fc42d02.y1 (e-PCR)
- UniSTS:193815

fb93g12.x1 (e-PCR)
- UniSTS:203544

fd13e04.x1 (e-PCR)
- UniSTS:195186

z42850b (e-PCR), detects polymorphism
- UniSTS:238459

fc07c10.x1 (e-PCR)
- UniSTS:203750

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 16-A

Names: plzfa; promyelocytic leukemia zinc finger protein-A; zinc finger and BTB domain containing 16; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199635.1 → NP_955929.1 zinc finger and BTB domain-containing protein 16-A

See identical proteins and their annotated locations for NP_955929.1

Status: PROVISIONAL

Source sequence(s)

BC046887

UniProtKB/Swiss-Prot

Q802Y8

Related

ENSDARP00000153802.1, ENSDART00000184419.1

Conserved Domains (6) summary

smart00225
Location:35 → 106

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:445 → 620

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:546 → 566

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:515 → 537

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:25 → 106

BTB; BTB/POZ domain

pfam13465
Location:559 → 582

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

23163987..23307796 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009295291.4 → XP_009293566.1 zinc finger and BTB domain-containing protein 16-A isoform X1

UniProtKB/TrEMBL

A0A8M3ATT4, E7FDS7

Related

ENSDARP00000024790.8, ENSDART00000007806.9

Conserved Domains (6) summary

smart00225
Location:35 → 106

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:445 → 619

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:517 → 537

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:515 → 537

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:25 → 106

BTB; BTB/POZ domain

pfam13465
Location:558 → 581

zf-H2C2_2; Zinc-finger double domain