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    cpn1 carboxypeptidase N, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 337172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpn1provided by ZNC
    Official Full Name
    carboxypeptidase N, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9116
    See related
    Ensembl:ENSDARG00000005185 AllianceGenome:ZFIN:ZDB-GENE-030131-9116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1037; fa99g08; zgc:77485; wu:fa99g08
    Summary
    Predicted to enable metallocarboxypeptidase activity. Acts upstream of or within cellular response to estrogen stimulus; liver development; and sprouting angiogenesis. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin cartilage; and vasculature. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cpn1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (31616515..31631297)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (31501613..31516395)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein 6 Neighboring gene uncharacterized LOC137496772 Neighboring gene dynamin binding protein Neighboring gene hyaluronan binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Liu LY, et al. Dis Model Mech, 2013 Sep. PMID 23813869, Free PMC Article
    2. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Li RF, et al. Biomedicines, 2022 May 27. PMID 35740282, Free PMC Article
    3. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development. Wu TY, et al. Sci Rep, 2017 May 12. PMID 28500283, Free PMC Article
    4. Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. Iwanami N, et al. iScience, 2020 Jul 24. PMID 32585597, Free PMC Article
    5. Identification of estrogen target genes during zebrafish embryonic development through transcriptomic analysis. Hao R, et al. PLoS One, 2013. PMID 24223173, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase N catalytic chain
    NP_997935.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212770.1 → NP_997935.1  carboxypeptidase N catalytic chain precursor

      See identical proteins and their annotated locations for NP_997935.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066689
      UniProtKB/TrEMBL
      Q6NY94
      Related
      ENSDARP00000108195.2, ENSDART00000124439.3
      Conserved Domains (2) summary
      cd03864
      Location:29 → 339
      M14_CPN; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase N subgroup
      cd11308
      Location:343 → 417
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      31616515..31631297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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