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    tubg1 tubulin, gamma 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tubg1provided by ZNC
    Official Full Name
    tubulin, gamma 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-836
    See related
    Ensembl:ENSDARG00000015610 AllianceGenome:ZFIN:ZDB-GENE-040426-836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tubgl; zgc:55894
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Predicted to act upstream of or within cytoplasmic microtubule organization. Predicted to be located in cytoskeleton. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in blastomere; oocyte stage III; and oocyte stage V. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tubg1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (37059806..37082618, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36917948..36940760, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490132 Neighboring gene si:ch211-18i17.2 Neighboring gene reticulophagy regulator family member 3 Neighboring gene PSMC3 interacting protein Neighboring gene MAX dimerization protein MLX

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. γ-Tubulin small complex formation is essential for early zebrafish embryogenesis. Pouchucq L, et al. Mech Dev, 2018 Dec. PMID 30426927
    2. Changes of gamma-tubulin expression and distribution in the zebrafish (Danio rerio) ovary, oocyte and embryo. Liu J, et al. Gene Expr Patterns, 2008 Apr. PMID 18243062
    3. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC55894, MGC174841

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule nucleator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin ring complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin gamma-1 chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320515.1 → NP_001307444.1  tubulin gamma-1 chain isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      CT573704
      UniProtKB/TrEMBL
      A0A8M1P8D3, B0JZL0
      Related
      ENSDARP00000101618.1, ENSDART00000110716.3
      Conserved Domains (2) summary
      cd02188
      Location:3 → 231
      gamma_tubulin; The gamma-tubulin family
      pfam00091
      Location:4 → 214
      Tubulin; Tubulin/FtsZ family, GTPase domain

    2. NM_200908.2 → NP_957202.1  tubulin gamma-1 chain isoform 1

      See identical proteins and their annotated locations for NP_957202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CT573704, EH487910, EH600327
      UniProtKB/TrEMBL
      A0A8M1PDN4, Q7ZVM5
      Related
      ENSDARP00000016775.8, ENSDART00000026701.9
      Conserved Domains (1) summary
      cd02188
      Location:3 → 435
      gamma_tubulin; The gamma-tubulin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      37059806..37082618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353659.3 → XP_017209148.1  tubulin gamma-1 chain isoform X1

      UniProtKB/TrEMBL
      A0A8M6YXT8
    Nucleotide Protein Strain
    Heading Accession and Version

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