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    thoc1 THO complex 1 [ Danio rerio (zebrafish) ]

    Gene ID: 373077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc1provided by ZNC
    Official Full Name
    THO complex 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-9
    See related
    Ensembl:ENSDARG00000088246 AllianceGenome:ZFIN:ZDB-GENE-030826-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    p84; Tho1
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Acts upstream of or within regulation of apoptotic process. Predicted to be located in cytosol; nuclear matrix; and nucleoplasm. Predicted to be part of THO complex part of transcription export complex. Is expressed in nervous system; otic vesicle; pectoral fin; and post-vent region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See thoc1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2772540..2790563)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2930641..2948664)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 13 Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 1 Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 2 Neighboring gene ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) Neighboring gene Rho-associated, coiled-coil containing protein kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sublethal effects of waterborne uranium exposures on the zebrafish brain: transcriptional responses and alterations of the olfactory bulb ultrastructure. Lerebours A, et al. Environ Sci Technol, 2010 Feb 15. PMID 20088580
    2. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. Zhang L, et al. PLoS Genet, 2020 Aug. PMID 32776944, Free PMC Article
    3. Newly identified Gon4l/Udu-interacting proteins implicate novel functions. Tsai SM, et al. Sci Rep, 2020 Aug 26. PMID 32848183, Free PMC Article
    4. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Inohara N, et al. Cell Death Differ, 2000 May. PMID 10917738
    5. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
      Title: THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201324.1 → NP_958481.1  THO complex subunit 1

      See identical proteins and their annotated locations for NP_958481.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054938
      UniProtKB/Swiss-Prot
      Q7SYB2
      Related
      ENSDARP00000105643.1, ENSDART00000124882.4
      Conserved Domains (2) summary
      cd08318
      Location:568 → 653
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:74 → 544
      efThoc1; THO complex subunit 1 transcription elongation factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      2772540..2790563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SYB2.1 GenPept UniProtKB/Swiss-Prot:Q7SYB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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