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    kat5a K(lysine) acetyltransferase 5a [ Danio rerio (zebrafish) ]

    Gene ID: 436638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kat5aprovided by ZNC
    Official Full Name
    K(lysine) acetyltransferase 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-57
    See related
    Ensembl:ENSDARG00000004587 AllianceGenome:ZFIN:ZDB-GENE-040718-57
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92510
    Summary
    Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Acts upstream of or within primitive erythrocyte differentiation. Predicted to be located in chromatin. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in dorsal telencephalon. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kat5a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23597140..23605946)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23093290..23102148)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene CWC15 spliceosome associated protein homolog Neighboring gene family with sequence similarity 76 member B Neighboring gene myotubularin related protein 2 Neighboring gene gap junction protein beta 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish. Zhou WH, et al. J Biol Chem, 2023 Oct. PMID 37660921, Free PMC Article
    2. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. Sun K, et al. iScience, 2023 Nov 17. PMID 37867960, Free PMC Article
    3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    4. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Fellous A, et al. Gene, 2019 Apr 5. PMID 30615915
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase KAT5a
    NP_001002365.1
    XP_005165196.1
    XP_009299572.1
    XP_009299573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002365.1 → NP_001002365.1  histone acetyltransferase KAT5a

      See identical proteins and their annotated locations for NP_001002365.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076045
      UniProtKB/TrEMBL
      A0A8M1N097, Q6DHD0
      Related
      ENSDARP00000030282.5, ENSDART00000032909.5
      Conserved Domains (3) summary
      pfam01853
      Location:316 → 499
      MOZ_SAS; MOZ/SAS family
      pfam11717
      Location:8 → 65
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:247 → 535
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23597140..23605946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165139.5 → XP_005165196.1  histone acetyltransferase KAT5a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCF7, B0R0X6
      Related
      ENSDARP00000113020.1, ENSDART00000142420.3
      Conserved Domains (3) summary
      pfam01853
      Location:295 → 478
      MOZ_SAS; MOZ/SAS family
      pfam11717
      Location:8 → 65
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:226 → 514
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. XM_009301297.4 → XP_009299572.1  histone acetyltransferase KAT5a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AS91
      Conserved Domains (3) summary
      pfam01853
      Location:293 → 476
      MOZ_SAS; MOZ/SAS family
      pfam11717
      Location:8 → 65
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:224 → 512
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. XM_009301298.4 → XP_009299573.1  histone acetyltransferase KAT5a isoform X3

      UniProtKB/TrEMBL
      A0A8M3B2B3
      Conserved Domains (3) summary
      COG5027
      Location:11 → 484
      SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
      pfam11717
      Location:8 → 65
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:203 → 491
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version

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