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    ANPEP alanyl aminopeptidase, membrane [ Bos taurus (domestic cattle) ]

    Gene ID: 404191, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ANPEPprovided by VGNC
    Official Full Name
    alanyl aminopeptidase, membraneprovided by VGNC
    Primary source
    VGNC:VGNC:25960
    See related
    BGD:BT15243; EnsemblRapid:ENSBTAG00070010759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    APN; CD13; P150
    Orthologs
    human mouse all
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    Genomic context

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    See ANPEP in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (21195687..21225009, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443240 Neighboring gene mesoderm posterior bHLH transcription factor 2 Neighboring gene adaptor related protein complex 3 subunit sigma 2 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene actin related protein 2/3 complex inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Kwon HJ, et al. Jpn J Cancer Res, 2002 Apr. PMID 11985792, Free PMC Article
    2. Interspecies aminopeptidase-N chimeras reveal species-specific receptor recognition by canine coronavirus, feline infectious peritonitis virus, and transmissible gastroenteritis virus. Benbacer L, et al. J Virol, 1997 Jan. PMID 8985407, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APN activity is not responsible for betulinic acid-inhibited growth factor-induced angiogenesis in endothelial cells
      Title: Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase N
    Names
    AP-M
    AP-N
    alanyl (membrane) aminopeptidase
    aminopeptidase M
    bAPN
    microsomal aminopeptidase
    NP_001068612.1
    XP_024837385.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075144.1 → NP_001068612.1  aminopeptidase N

      See identical proteins and their annotated locations for NP_001068612.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105142
      UniProtKB/Swiss-Prot
      P79098, Q3MHR1
      Related
      ENSBTAP00070014395.1, ENSBTAT00070024174.1
      Conserved Domains (3) summary
      cd09601
      Location:81 → 548
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:72 → 477
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:619 → 942
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21195687..21225009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981617.2 → XP_024837385.1  aminopeptidase N isoform X1

      UniProtKB/TrEMBL
      F1MN84
      Conserved Domains (2) summary
      cd09601
      Location:81 → 548
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam11838
      Location:618 → 945
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79098.4 GenPept UniProtKB/Swiss-Prot:P79098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.