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    ERLIN2 ER lipid raft associated 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 616278, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ERLIN2provided by VGNC
    Official Full Name
    ER lipid raft associated 2provided by VGNC
    Primary source
    VGNC:VGNC:28589
    See related
    BGD:BT18586; Ensembl:ENSBTAG00000017831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ERLIN2 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (33016636..33033830)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344065 Neighboring gene elongation factor 1-beta-like Neighboring gene uncharacterized LOC112444622 Neighboring gene pyridoxal phosphate binding protein Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene BRF2 RNA polymerase III transcription initiation factor subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137889

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    erlin-2
    Names
    SPFH domain-containing protein 2
    endoplasmic reticulum lipid raft-associated protein 2
    stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046576.1 → NP_001040041.1  erlin-2

      See identical proteins and their annotated locations for NP_001040041.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114707
      UniProtKB/Swiss-Prot
      Q1RMU4
      Related
      ENSBTAP00000039591.2, ENSBTAT00000039803.3
      Conserved Domains (2) summary
      smart00244
      Location:21 → 187
      PHB; prohibitin homologues
      cd03406
      Location:16 → 308
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33016636..33033830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226124.5 → XP_005226181.1  erlin-2 isoform X1

      UniProtKB/TrEMBL
      A0AAF7ABD1
      Related
      ENSBTAP00000066190.2, ENSBTAT00000085899.2
      Conserved Domains (2) summary
      smart00244
      Location:101 → 267
      PHB; prohibitin homologues
      cd03406
      Location:96 → 388
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. XM_005226125.5 → XP_005226182.1  erlin-2 isoform X2

      See identical proteins and their annotated locations for XP_005226182.1

      UniProtKB/TrEMBL
      A0AAA9TYU4
      Related
      ENSBTAP00000103512.1, ENSBTAT00000087622.1
      Conserved Domains (2) summary
      smart00244
      Location:35 → 201
      PHB; prohibitin homologues
      cd03406
      Location:30 → 322
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. XM_005226126.5 → XP_005226183.1  erlin-2 isoform X3

      See identical proteins and their annotated locations for XP_005226183.1

      UniProtKB/Swiss-Prot
      Q1RMU4
      Conserved Domains (2) summary
      smart00244
      Location:21 → 187
      PHB; prohibitin homologues
      cd03406
      Location:16 → 308
      SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RNA

    1. XR_816034.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RMU4.1 GenPept UniProtKB/Swiss-Prot:Q1RMU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.